Ocular IgE

Immunoglobulin E (IgE) is a class of antibody that is found only in mammals. While it’s main biological function is providing immunity to certain parasites, IgE also plays an important role in Type 1 hypersensitivity, which manifests various allergic diseases such as asthma, allergic rhinitis, food allergies and allergic conditions, such as anaphylactic reactions to certain allergens.

IgE that can specifically recognize an allergen has a long lived interaction with its high affinity receptor and “primes” basophils and mast cells, capable of mediating inflammatory reactions, for the release of chemicals like histamine, leukotrienes and certain interleukins. These chemicals cause many of the traditional symptoms associated with allergic response such as vascular constriction, inflammation, itching, increased mucous secretion, etc.

Tear IgE has long been established to play an important role in allergic conjunctivitis, thus, the measurement of tear IgE concentrations can be used to confirm the condition. Additionally, locally produced IgE levels in the tear film do not routinely correlate with systemic IgE and have been shown to be the largest contributor to the severity of allergic conjunctivitis.

ATD’s IgE test is an FDA cleared lab test for confirming allergic conjunctivitis using a testing platform that is accurate, rapid, simple and reimbursable.